P-49: Protective Effect of Grape Seed Extraction on Dexamethason Induced Spermatogenesis Defect in Mice

Background Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system .The present study investigates the efficacy grape seeds , source of the most useful groups of plant flavonoids, phenolic procyanids, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. MaterialsAndMethods A total of 32 male mice were divided into four groups (8 mice each). The first group served as control and received distill water only for 25 days. Mice of the second group received Dex at the dose of 7 mg/kg body weight by i.p. injection for 7 days. Mice of the third group received efficacy grape seeds extract at a dose of 100 ml/kg body weight. The fourth group received efficacy grape seeds extract at the dose of 100 mg/kg for 25 days and Dex at the same dose of the second group was injected during the last 7 (18 to 25) days. Statistical significance was determined using one-way analysis of varianc (ANOVA)followedby Tukey- Kramer multiple comparison tests. A P value